Isolation, Natural product chemistry, Total synthesis, Computer chemistry, Microbiology

A single-step synthesis of farinomalein A, a naturally occurring maleimide, by the radical-mediated introduction of an isopropyl group to bromomaleic anhydride and one-pot maleimide formation with β-alanine is reported. Antimicrobial testing of natural and unnatural farinomaleins synthesized using this protocol demonstrates that farinomalein A and some unnatural analogs are active against Bacillus subtilis , and one unnatural analog is active against Escherichia coli . The possible inhibitory activity of bacterial membrane and/or cell wall functions of farinomalein A was indicated by cell morphological studies.

The intramolecular Diels-Alder reaction was employed for the assembly of the trans -decalin structure of cladoic acid, an anti-Trypanosoma cruzi active polyketide isolated from a fungus of the genus Cladosporium . Although the cycloaddition provided the desired trans -octalin as a minor product, the method was effective for simultaneously constructing four stereocenters in the B-ring of cladoic acid.

Bacteria are the most important source for the discovery of novel compounds. Bioactive metabolites obtaining from bacteria play a vital role to treat various infectious diseases and cancers. For this reason, the main objective of this study was to isolate and evaluate the anticancer activities of bioactive metabolites from a bacterium, DADA-1AIMR-24 against Ehrlich ascites carcinoma cell (EAC) using 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The bioactive metabolites were also tested for their anticancer activity against human head and neck cancer cell 93-VU-147T and TU686. The metabolites showed prominent cytotoxic activity in vitro against human head and neck cancer cell lines. The metabolites showed 100% of inhibition at the concentration of 62.5μg/ml against Ehrlich ascites carcinoma (EAC) cell. The results indicated that bioactive metabolites of DADA-1AIMR-24 have a good anticancer activity and could be useful to identify novel molecules with potential anticancer drugs for chemotherapeutic use.

The aim of this study was to screen antibacterial, antifungal and cytotoxic activities of crude metabolites of a bacterium DADA-1AIMR-24 isolated from soil in Rajshahi division, Bangladesh. The antibacterial activity of crude extracts was tested by agar well diffusion technique against Bacillus cereus, Staphylococcus aureus ATCC-259233, Listeria monocytogenes, Agrobacterium spp., Escherichia coli FPFC- 1407, Shigella dysenteriae AL-35587, Shigella sonnei and Shigella boydii. At the same time, antifungal activity was also conducted by disc diffusion method against Aspergillus niger, Tichoderma herzanium, and Microphomina phaseolina. The MIC values of the extract against Bacillus cereus, Staphylococcus aureus ATCC-259233, E. coli FPFC-1407, Shigella dysenteriae AL-35587, Shigella sonnei, Shigella boydii were 64, 64, 64, 64, 64 and 32 μg/ml respectively. The minimum bactericidal concentration (MBC) was also determined (Table 2). The MBC values of the extract were 128, 128, 128, 128, 128 and 64 μg/ml. As the MBC value was higher than the MIC value, it is clear that the extract was bacteriosatic not bactericidal. The approximate counts of bacteria in the MIC tubes were also determined (table 2). The brine shrimp lethality bioassay was conducted to determine the cytotoxic nature of crude extracts, which showed that the degree of lethality of extracts was directly proportional to the concentration (LC50 21.55 μg/ml) compounds in the crude extract but due to low production of metabolites, we could not extract sufficient amounts as it took long time to produce metabolites. Further work is necessary to isolate and characterize the active compounds.

Assistant Professor at Dept. of Pharmacy with a demonstrated history of taking internship in the pharmaceuticals industry. Skilled in Research on Phytochemistry (invitro & invivo) & Molecular biology, Microsoft Office, Strategic Planning, Adobe Illustrator, and Public Speaking. Strong education professional with a M. Pharm (Thesis) focused on Antioxidant activity from University of Rajshahi with a training on biotechnology techniques at National Institute of Biotechnology, Bangladesh.

Pharmacology, Phytochemistry, Molecular Biology

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https://scholar.google.com/citations?user=mCuvsvcAAAAJ&hl=en

Research article of my M. Pharm. (Thesis)

Review article on Covid-19

Case study: Survey-based article

Laboratory research article 

Review article on Herbal Medicinal Plant

Nanotechnology, Drug Delivery, Formulation, Pharmacokinetics

https://www.researchgate.net/profile/Milon-Ghosh?ev=hdr_xprf

https://scholar.google.com/citations?user=-WNc0zwAAAAJ&hl=en

Rifampicin (RIF) is a first-line antitubercular (anti-Tb) drug despite its decreased oral bioavailability and remarkable hepatotoxicity owing to its poor aqueous solubility. A coconut oil-based RIF-loaded self-nanoemulsifying drug delivery system (RF1) was developed beforehand to resolve the solubility issue. This work aimed to appraise the pharmacokinetic (PK) profiles and safety properties of RF1 for future endeavors.

The aim of present investigation was to develop self-nanoemulsifying drug delivery system of rifampicin (RIF) using vegetable oils for improved drug release and tuberculostatic activity (TSA).

In developing countries, the use of generic medicine as a cost-saving measure in health care provision has been increasing daily. Alverine citrate (ALV), a smooth muscle relaxant, is Available in the form of Tablets from different pharmaceutical companies in the local market of Bangladesh.

Quetiapine fumarate (QF) is a drug frequently prescribed to treat various psychotic conditions such as bipolar disorder and SCZ (schizophrenia). More than 50 companies in Bangladesh manufacture this generic. The use of substandard or counterfeit medicines may worsen the disease condition and significantly reduce patient quality of life. As there is a vast opportunity to use low-cost generic products, we aimed this project to evaluate whether these QF brands meet the in-vitro quality control parameters for ensuring pharmacopoeial criteria. 

Cefuroxime Axetil (CA) a widely used cephalosporin antibiotic displays low aqueous solubility and high membrane penetrability. This results in its solubility driven variable and/or low oral bioavailability and therapeutic efficacy as a major drawback. Thus, most of the goal of our study was to increase the solubility as well as dissolution rate of CA using the simple and cost-effective solid dispersion (SD) method.

Paracetamol (PCM) is enlisted in the WHO model list as an essential medicine for pain and palliative care, but at overdose, it causes hepatic damage. This study was designed to assess the analgesic efficacy and hepatoprotective property of a solid dispersion (SD) loaded with PCM.

Hyperlipidaemia is a common phenomenon in diabetes mellitus. Fenofibrate (FF) is a good candidate for the treatment of lipid abnormalities in patients with type 2 diabetes. But the bioavailability as well as therapeutic efficacy of this drug is limited to its dissolution behaviour. Here, the authors assess the therapeutic efficacy of a newly formulated solid dispersion of fenofibrate (SDF) having enhanced dissolution profiles in contrast to pure FF using fructose-induced diabetic rat model.

Fenofibrate (FF) is an anti-hyperlipidaemic drug belonging to BCS class-II (low solubility, high permeability). Its bioavailability is limited by the dissolution rate. This study was aimed to enhance the rate of dissolution of poorly water soluble drug, FF.

Medicinal plants are emerging ever-increasing demand day by day because of their significant pharmacological values with low cost and less toxicity than the corresponding synthetic chemical entities. These plants have been used since very long times in the traditional folk medicine. 

  The purpose of this Post-Marketing Pharmaceutical Quality Evaluation of Cefuroxime Axetil 500 mg tablets to evaluate the quality standards of different marketed brands with various price ranges, collected from retail drug stores of Bangladesh.

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